FBXW7 E3 ubiquitin ligase: degrading, not degrading, or being degraded
نویسندگان
چکیده
منابع مشابه
Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and triggers the unfolded protein response (UPR). Failure to resolve ER stress leads to apoptotic cell death via a yet unclear mechanism. Here, we show that RNF183, a membrane-spanning RING finger protein, localizes to the ER and exhibits classic E3 ligase activities. Sustained ER stress induced by differe...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2019
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-019-0652-x